Selected Sources of Research and Medical References:
American Heart Association Scientific Statement: Fish Consumption, Fish Oil, Omega-3 Fatty Acids and Cardiovascular Disease, #71-0241 Circulation. 2002;106: 2747-2757
American Heart Association Scientific Statement: AHA Dietary Guidelines: Revision 2000, #71-0193 Circulation. 2000;102:2284-2299; Stroke. 2000;31:2751-2766
Prostaglandins Leukotrienes and Essential Fatty Acids 69(4):237-243, 2003
Hutchins AM et al. “Flaxseed consumption influences endogenous hormone concentrations in postmenopausal women.” Nutr Cancer, 39, 1:58-65, 2001.
Lucas EA et al. “Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women.” J Clin Endocrinol Metab. 87(4):1527-32, 2002.
Caughey GE et al. “The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil.” Am J Clin Nutr, 63, 1:116-22, 1996.
Ranich T et al. “Protective effects of dietary phytoestrogens in chronic renal disease.” J Ren Nutr, 11, 4:183-93, 2001.
Lemay A et al. “Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women.” Obstet Gynecol, 100, 3:495-504, 2002.
Tate, F., D., Wind, R., R., & Winlett, R., A. (2001). Using Internet technology to deliver a behavioral weight loss program. The Journal of the American Medical Association, 225 (9), 1172-1177.
Harvey-Berino, J., Pintauro, J., S., & Gold, C., E. (2002). The feasibility of using Internet support for the maintenance of weight loss. Behavior Modification, 26 (1), 103-116.
Oenema, A., Brug, J., & Lechner, L. (2001).Web-based tailored nutrition education: results of a randomized controlled trial. Health Education Research, 16 (6), 647-660.
de la Fuente M, Ferrandez MD, Burgos MS, et al. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998;76:373-80.
Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J “Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.” Am J Clin Nutr 1999 Dec;70(6):1040-5.
Oakley GP Jr. Eat right and take a multivitamin. New England Journal of Medicine 1998;338:1060-1 [editorial].
Cracium AM, Wolf J, Knapen MJH, et al. Improved bone metabolism in female elite athletes after vitamin K supplementation. Int J Sports Med 1998;19:479-84.
Fairburn K, Grootveld M, Ward RJ, et al. Alpha-tocopherol, (vitamin E) lipids and lipoproteins in knee-joint synovial fluid and serum from patients with inflammatory joint disease. Clin Sci 1992;83:657-64.
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. “Osteoporosis prevention, diagnosis, and therapy.” Journal of the American Medical Association 2001 Feb 14;285(6):785-95.
McKane WR, et al. “Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption.” Journal of Clinical Endocrinology and Metabolism 1996 May; 81(5):1699-703.
Huuskonen J, et al. “Determinants of bone mineral density in middle aged men: a population-based study.” Osteoporosis International 2000;11(8):702-8.
Rucker RB, Kosonen T, Clegg MS, et al. Copper lysyl oxidase, and extracellular matrix protein cross-linking. Am J Clin Nutr 1998;67(5 suppl):996s-1002s.
Newnham RE. Arthritis or skeletal fluorosis and boron. Int Clin Nutr Rev 1991;11:68-70 [letter].
Fraker PJ, Gershwin ME, Good RA, Prasad A. Interrelationships between zinc and immune function. Fed Proc 1986;45:1474-9.
Tarp U, Overvad K, Hansen JC, Thorling EB. Low selenium level in severe rheumatoid arthritis. Scand J Rheumatol 1985;14:97-101.
Peretz A, Neve J, Duchateau J, Famaey JP. Adjuvant treatment of recent onset rheumatoid arthritis by selenium supplementation: preliminary observations [letter]. Br J Rheumatol 1992;31:281-2.
DiSilvestro RA, Marten J, Skehan M. Effects of copper supplementation on ceruloplasmin and copperzinc superoxide dismutase in freeliving rheumatoid arthritis patients. J Am Coll Nutr 1992;11:177-80.
Sorenson JRJ. Copper complexes-a unique class of antiarthritic drugs. Progress Med Chem 1978;15:211-60 (review).
Carl Germano and William Cabot, in their book Nature’s Pain Killers (Kensington Books, NY)
Caso Marasco A, Vargas Ruiz R, Salas Villagomez A, Begona Infante C “Double-blind study of a multivitamin complex supplemented with ginseng extract.” Drugs Exp Clin Res 1996;22(6):323-9.
Scaglione F, Ferrara F, Dugnani S, et al. Immunomodulatory effects of two extracts of Panax ginseng CA Meyer. Drugs Exptl Clin Res 1990;16:537-42.
Baranov AI. Medicinal uses of ginseng and related plants in the Soviet Union: Recent trends in the Soviet literature. J Ethnopharmacol 1982;6:339-53 [review].
Caso Marasco A, Vargas Ruiz R, Salas Villagomez A, Begona Infante C “Double-blind study of a multivitamin complex supplemented with ginseng extract.” Drugs Exp Clin Res 1996;22(6):323-9.
Vogler BK, Pittler MH, Ernst E: The efficacy of ginseng. A systematic review of randomized clinical trials. European Journal of Clinical Pharmacology, 55(8):567-75, 1999.
Pieralisi G, Ripari P, Vecchiet L, et al: Effects of standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 13:372-382, 1991.
D’Angelo L, Grimaldi R, Caravaggi M, et al: A double blind, placebo-controlled study on the effect of a standardized ginseng extract on psychomotor performance on healthy volunteers. Journal of Ethnopharmacol 16:15-22, 1986.
Nanba H. Anti-tumor activity of orally administered ‘D-fraction’ from maitake mushroom (Grifola frondosa). J Naturopathic Med 1993;4:10-5.
Pengelly A. Medicinal fungi of the world. Modern Phytotherapist 1996;2:1,3-8 [review].
Hamilton-Miller JM. Antimicrobial properties of tea (Camellia sinensis L.). Antimicrob Agents Chemother 1995;39:2375-7.
Fraker PJ, Gershwin ME, Good RA, Prasad A. Interrelationships between zinc and immune function. Fed Proc 1986;45:1474-9.
de la Fuente M, Ferrandez MD, Burgos MS, et al. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 1998;76:373-80.
McKane WR, et al. “Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption.” Journal of Clinical Endocrinology and Metabolism 1996 May;81(5):1699-703.
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. “Osteoporosis prevention, diagnosis, and therapy.” Journal of the American Medical Association 2001 Feb 14;285(6):785-95.
Huuskonen J, et al. “Determinants of bone mineral density in middle aged men: a population-based study.” Osteoporosis International 2000;11(8):702-8.
Zempleni J, et al. “Utilization of biotin in proliferating human lymphocytes.” Journal of Nutrition 2000 Feb;130(2S Suppl):335S-337S.
Welten DC, Kemper HCG, Post GB, van Stavberen WA. A meta-analysis of the effect of calcium intake on bone mass in young and middle aged females and males. J Nutr 1995;125:2802-13.
Brennan LA, et al. “The effect of vitamin C or vitamin E supplementation on basal and H202-induced DNA damage in human lymphocytes.” British Journal of Nutrition 2000 Aug;84(2):195-202.
Weber P, et al. “Vitamin E and human health: rationale for determining recommended intake levels.” Nutrition 1997 May;13(5):450-60.
Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 1999;69:1086-107 [review].
Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23 [review].
Levine M, Conry-Cantilena C, Wang Y, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A 1996;93:3704-9.
Weber P, et al. “Vitamin C and human health – a review of recent data relevant to human requirements.” International Journal of Vitamin and Nutrition Research 1996;66(1):19-30.
Christian P, et al. “Vitamin A or beta-carotene supplementation reduces but does not eliminate maternal night blindness in Nepal.” Journal of Nutrition 1998 Sep;128(9):1458-63.
Khachik F, et al. “Identification of lutein and zeaxanthin oxidation products in human and monkey retinas.” Invest Ophthalmol Vis Sci 1997 Aug;38(9):1802-11.
Diamond T, Smerdely P, Kormas N, et al. Hip fracture in elderly men: the importance of subclinical vitamin D deficiency and hypogonadism. Med J Aust 1998;169:138-41.
Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996;347:781-6.
Ford ES, Sowell A. Serum alpha-tocopherol status in the United States population: findings from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 1999;150:290-300..
Raloff J. Reasons for boning up on manganese. Science News Sep 27, 1986:199 [review].
Anderson RA. Recent advances in the clinical and biochemical effects of chromium deficiency. Prog Clin Biol Res 1993;380:221-34 [review].
Davies S, McLaren Howard J, Hunnisett A, Howard M. Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients–implications for the prevention of cardiovascular disease and type II diabetes mellitus. Metabolism 1997;46:469-73.
Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr 1999;19:357-77 [review].
Verhaeverbeke I, Mets T, Mulkens K, Vandewoulde M. Normalization of low vitamin B12 serum levels in older people by oral treatment. J Am Geriatr Soc 1997;45:124-5 [letter].
Lobo A, Naso A, Arheart K, et al. Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12. Am J Cardiol 1999;83:821-5.
Williams MH, “Vitamin supplementation and athletic performance.” Int J Vitam Nutr Res Suppl 1989;30:163-91.
Ogorek CP, Davidson L, Fisher RS, Krevsky B “Idiopathic gastroparesis is associated with a multiplicity of severe dietary deficiencies.” Am J Gastroenterol 1991 Apr;86.
Brennan LA, et al. “The effect of vitamin C or vitamin E supplementation on basal and H202-induced DNA damage in human lymphocytes.” British Journal of Nutrition 2000 Aug;84(2):195-202.
Ye X, et al. “The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells.” Molecular Cellular Biochemistry 1999 Jun;196(1-2):99-108.
Clostre F. “Ginkgo biloba extract (Egb 761). State of knowledge in the dawn of the year 2000.” Ann Pharm Fr 1999 Jul;57 Suppl 1:1S8-88.
Penninx BW, et al. “Vitamin B12 deficiency and depression in physically disabled older women: epidemiologic evidence from the Women’s Health and Aging Study.” American Journal of Psychiatry 2000 May;157(5):715-21.
Langsjoen H, et al. “Usefulness of coenzyme Q10 in clinical cardiology: a long-term study.” Molecular Aspects of Medicine 1994;15 Suppl:s165-75.
Verhoef P, et al. “Folate and coronary heart disease.” Curr Opin Lipidol 1998 Feb;9(1):17-22.
Jotti A, et al. “Protective effect of dietary selenium supplementation on delayed cardiotoxicity of adriamycin in rat: is PHGPX but not GPX involved?” Free Radical Biology and Medicine 1994 Feb;16(2):283-8.
Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 1994;272:1413-20.
Jacques PF, Chylack LT Jr. Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Am J Clin Nutr 1991;53:352S-55S.
Levine M. Vitamin C and optimal health. Presented at the February 25, 1999 60th Annual Biology Colloquium, Oregon State University, Corvallis, Oregon.
Clark LC, et al. “Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial.” British Journal of Urology 1998 May;81(5):730-4.
Cohen L, Laor A, Kitzes R. Magnesium malabsorption in postmenopausal osteoporosis. Magnesium 1983;2:139-43.
Cohen L, Kitzes R. Infrared spectroscopy and magnesium content of bone mineral in osteoporotic women. Isr J Med Sci 1981;17:1123-5.
Geinster JY, Strauss L, Deroisy R, et al. Preliminary report of decreased serum magnesium in postmenopausal osteoporosis. Magnesium 1989;8:106-9.
Dimai H-P, Porta S, Wirnsberger G, et al. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab 1998;83:2742-8.
Eaton-Evans J, McIlrath EM, Jackson WE, et al. Copper supplementation and bone-mineral density in middle-aged women. Proc Nutr Soc 1995;54:191A.
Raloff J. Reasons for boning up on manganese. Science News 1986;Sep 27:199 [review].
Blonstein J. Control of swelling in boxing injuries. (Bromelain) Practitioner 1960;203:206.
Cohen A, Goldman J. Bromelains therapy in rheumatoid arthritis. Pennsylvania Med J 1964;67:27-30.
Cohen AJ, et al. “Ginkgo biloba for antidepressant-induced sexual dysfunction.” Journal of Sex and Marital Therapy 1998 Apr-Jun;24(2):139-43.
Sitaram N, et al. Choline: Selective Enhancement of Serial Learning and Encoding of Low Imagery Words in Man. Life Sci. May1978;22(17):1555-60.
Secades JJ, et al. CDP-choline: Pharmacological and Clinical Review. Methods Find Exp Clin Pharmacol. Oct1995;17(Suppl B):2-54.
Ferris SH, et al. Combination of Choline/Piracetam in the Treatment of Senile Dementia. Psychopharmacology Bulletin. 1982;18:94-98.
Cacabelos R, et al. A pharmacogenomic approach to Alzheimer’s disease. Acta Neurol Scand Suppl. 2000;176:12-9.
Friedland, J., et al. “Potassium and fatigue.” The Lancet. 2:961-962m, 1988.
Fang, J., Madhavan, S. and Alderman, M.H. (2000). Dietary potassium intake and stroke mortality. Stroke; 31:1532-1537.
Flyvbjerg, A. et al. “Evidence that potassium deficiency induces growth retardation through reduced circulating levels of growth hormone and insulin-like growth factor 1.” Metabolism; 40(8):769-775, 1991.
Sjogren, A., et al., “Magnesium deficiency in coronary artery disease and cardiac arrhythmias”, Journal of Intermal Medicine, 226:213-222, 1989
Classen, H.G; O., Fischer, G, et al. (1986): “Magnesium: Prevention of stress-induced cardiovascular damage,” Magnesium Bulletin 8, 140-144
Krishna, G., et al. Increased blood pressure during potassium depletion in normotensive men. The New England Journal of Medicine. 320:1177-1182, 1989.
Britton, J. et al. 1994: “Dietary Magnesium, lung function, wheezing, and airway hyperactivity in a random adult population sample.” Lancet; 344(8919): 357-62